Xin Yu, ScD

Research interests

Our laboratory is devoted to the development of magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) methods for integrative understanding of several prevalent diseases such as diabetes, stroke, and heart diseases. These diseases share a common underlying cause – metabolic dysfunction. We aim to develop state-of-the-art MRI and MRSI methods for noninvasive characterization of various aspects of tissue metabolism, from substrate delivery to oxygen utilization. Some of these technologies hold the potential for early detection of metabolic dysfunction. We also collaborate with investigators in basic science research to apply these technologies to laboratory animal models, including genetically engineered mouse models, for better understanding of the mechanisms leading to abnormal metabolism, and the response to therapeutic interventions.

Awards and Honors

• Fellow of International Society of Magnetic Medicine (ISMRM)
• Fellow of American Institute for Medical and Biological Engineering (AIMBE)
• Research Award, 2008, Case Western Reserve University School of Engineering
• Clement Vaturi Fellowship in Biomedical Engineering, 1994, Massachusetts Institute of Technology
• Clement Vaturi Fellowship in Biomedical Engineering, 1993, Massachusetts Institute of Technology
• Wolkman Fellowship of W.G.C. Whiting School of Engineering, 1990, The Johns Hopkins University
• Wolkman Fellowship of W.G.C. Whiting School of Engineering, 1989, The Johns Hopkins University

Professional Memberships

• International Society of Magnetic Resonance in Medicine
• American Association for the Advancement of Science
• American Heart Association
• American Diabetes Association
• International Society of Cerebral Blood Flow and Metabolism

Publications:

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Gu Y, Pan Y, Fang Z, Ma L, Zhu Y, Androjna C, Zhong K, Yu X, Shen D. Deep learning-assisted preclinical MR fingerprinting for sub-millimeter T₁ and T₂ mapping of entire macaque brain. Magn Reson Med. 2023 Nov 6. Epub ahead of print.

Zhu Y, Wang G, Kolluru C, Gu Y, Gao H, Zhang J, Wang Y, Wilson DL, Zhu X, Flask CA, Yu X. Transport Pathways and Kinetics of Cerebrospinal Fluid Tracers in Mouse Brain Observed by Dynamic Contrast-Enhanced MRI. Sci Rep. 2023 Aug 24;13(1):13882.

Gu Y, Wang L, Yang H, Wu Y, Kim K, Zhu Y, Androjna C, Zhu X, Chen Y, Zhong K, Yu X. Three-dimensional high-resolution T₁ and T₂ mapping of whole macaque brain at 9.4 T using magnetic resonance fingerprinting. Magn Reson Med. 2022 Jun;87(6):2901-2913.

Kim K, Gu Y, Wang CY, Clifford B, Huang S, Liang ZP, Yu X. Quantification of creatine kinase reaction rate in mouse hindlimb using phosphorus-31 magnetic resonance spectroscopic fingerprinting. NMR Biomed. 2021 Feb;34(2):e4435.

Gu Y, Gao H, Kim K, Liu Y, Ramos-Estebanez C, Luo Y, Wang Y, Yu X. Dynamic oxygen-17 MRI with adaptive temporal resolution using golden-means-based 3D radial sampling. Magn Reson Med. 2021 Jun;85(6):3112-3124.

Gu Y, Wang CY, Anderson CE, Liu Y, Hu H, Johansen ML, Ma D, Jiang Y, Ramos-Estebanez C, Brady-Kalnay S, Griswold MA, Flask CA, Yu X. Fast magnetic resonance fingerprinting for dynamic contrast-enhanced studies in mice. Magn Reson Med. 2018 Dec;80(6):2681-2690.

Wang CY, Liu Y, Huang S, Griswold MA, Seiberlich N, Yu X. ³¹ P magnetic resonance fingerprinting for rapid quantification of creatine kinase reaction rate in vivo. NMR Biomed. 2017 Dec;30(12):10.1002/nbm.3786.